Cancer Stem Cell Therapy is an emerging field in oncology that focuses on targeting cancer stem cells (CSCs)—a subpopulation of tumor cells responsible for cancer initiation, progression, and recurrence. These therapies aim to eliminate CSCs to prevent tumor relapse and resistance to conventional treatments. Cancer stem cell therapy utilizes targeted approaches, immunotherapy, gene therapy, and novel drug delivery systems to disrupt CSC signaling pathways and improve treatment efficacy. To develop effective therapies, researchers and clinicians collaborate across disciplines, integrating molecular biology, regenerative medicine, and oncology to design innovative treatment strategies tailored to patient needs.