Advancing from phenomenological, evidence-based, person-centered, and personalized care, health ecosystems currently undergo a transformation towards personalized, preventive, predictive, participative precision medicine (5PM), supported by technology. It considers individual health status, conditions, genetic and genomic dispositions in personal social, occupational, environmental and behavioral context, understanding the pathology of diseases and turning health and social care from reactive to proactive. Thereby, we have to enable communication and cooperation between all actors from different knowledge spaces including the subject of care, representing different disciplines, using different methodologies, perspectives, intentions, languages, etc., based on different educations and skills. Therefore, the knowledge-based, multidisciplinary, highly complex and highly dynamic 5PM ecosystem must be consistently and formally represented. The outcome is a system-theoretical, context-sensitive, architecture-centric, ontology-based, policy-driven approach for designing and managing intelligent, ethical and sustainable 5PM ecosystems, developed by the author and internationally standardized. The deployment of the approach is meanwhile defined by leading standards developing organizations such as ISO, CEN, IEEE, etc., as mandatory for all projects covering more than just one domain.

Dr. Bernd Blobel received a multi-disciplinary education, covering mathematics, physics, systems engineering, electronics, medicine, informatics and medical informatics, including habilitations in medicine and informatics. He was Head of the Institute for Biometrics and Medical Informatics at the University of Magdeburg, and then Head of the Health Telematics Project Group at the Fraunhofer IIS in Erlangen. Thereafter, he acted until his retirement as Head of the German National eHealth Competence Center at the University of Regensburg. He was leadingly involved in many countries health digitalization as well as electronic health record strategy. He was and is still engaged in international standardization at ISO, CEN, HL7, OMG, IEEE etc. Furthermore, he still engaged in international higher education.