Background- Preeclampsia (PE) is a major obstetric problem contributing considerably to maternal and prenatal morbidity and mortality worldwide.  PE has an underlying mechanism of endothelial dysfunction and elevated immune response. So our Aim to evaluate the systemic inflammatory markers and their ratio such as NLR and PLR in early pregnancy and correlate with the development of Preeclampsia. Material & Methods- This case-control study, 100 pregnant women aged between 18-40 years and at less than 16 weeks POG were taken for analysis in the study.  CBC including hemoglobin, differential leukocyte counts and their ratio NLR and PLR were measured at 12-16 weeks. All pregnant women were followed till delivery to measure outcome like development of preeclampsia. Result:  Data of 30 pregnant women with PE and 70 women age and gestation matched normotensive (NT) pregnant women were compared. Mean age and gestational age were comparable within 2 groups. The BMI and NLR were significantly more in women developing PE later while no significant difference was seen in the PLR between groups showing in table number 1. The positive predictive value of NLR for preeclampsia was determined by ROC analysis. On the basis of ROC curve, the most discriminates NLR value at 12-16 wks for prediction of development of PE was 3.20 which gave the good sensitivity and specificity as 70% and 64% respectively with probability 0.74.  Conclusions- This study suggests that first-trimester NLR may be a part of first-trimester screening to identify a significant proportion of high-risk women that subsequently develop PE.

Mrs. Tarang Gupta has completed his Master degree in Biotechnology at the age of 21 years from Jiwaji University, MP, India and pursuing PHD in life sciences studies from Singhania University, Rajasthan, India. She is a Scientist-1, in department of Obstetrics and gynecology, AIIMS, New Delhi organization. She has published more than 10 papers in reputed journals.