COVID-19 issues and management involve addressing the pandemic's widespread impact on public health, healthcare systems, and economies. Key challenges include the rapid transmission of the virus, healthcare worker shortages, and the mental health crisis stemming from isolation and uncertainty. Effective management strategies encompass widespread vaccination campaigns, implementation of public health measures (such as masking and social distancing), and enhanced testing and contact tracing protocols. Telehealth has gained prominence to maintain access to healthcare while minimizing virus exposure. Ongoing research on variants and long-term effects is essential for adapting responses and preparing for future public health challenges related to infectious diseases.