Eastern Equine Encephalitis (EEE) is a rare but serious viral disease caused by the Eastern Equine Encephalitis virus, primarily transmitted by mosquitoes. It primarily affects horses and humans, leading to inflammation of the brain. Symptoms in humans can include fever, chills, and headache, which may progress to neurological signs such as confusion, seizures, and coma. The disease has a high mortality rate, especially in severe cases. Prevention focuses on mosquito control and vaccination for horses. There is no specific antiviral treatment, so supportive care is crucial for affected individuals.