General internal medicine practitioners, referred to as general medicine physicians in some countries, are skilled in managing intricate, multisystem diseases beyond the scope of single-organ specialists. They handle perplexing cases like dyspnea, fatigue, and chest pain, which don't neatly fit into organ-specific categories. These experts address acute illnesses impacting multiple organs simultaneously, along with various chronic conditions in one patient. They possess comparable expertise to single-organ specialists, focusing on intricate comorbidities. It's important to note that internists, qualified physicians with advanced internal medicine training, differ from interns, first-year residents. While internists can be primary caregivers, they aren't family physicians, who cover broader medical areas. The American College of Physicians defines internists as specialists in preventing, identifying, and treating adult illnesses.