The COVID-19 pandemic poses an unprecedented public health threat, with SARS-CoV-2 primarily spreading through respiratory droplets from infected individuals, such as during coughing or sneezing. Direct transmission occurs through contact with saliva, respiratory secretions, or droplets expelled during speaking, coughing, or sneezing, while indirect transmission happens via contaminated surfaces (fomites) that can infect individuals who touch these surfaces and then their faces. In the realm of medicine, nanoparticles (NPs) are heralded for their revolutionary potential in precise disease diagnosis and treatment due to their small size, low toxicity, electrical charge, and chemical versatility, which help overcome administration challenges. This has led many researchers and companies to pivot from traditional approaches to combating SARS-CoV-2 towards exploring nanotechnology for the development of vaccines and therapies. This shift underscores a new frontier in research and development, emphasizing the role of nanotechnology and nanomedicine in creating innovative solutions to address the challenges posed by the virus.