Background: Neuroinflammation has gained substantial attention for its involvement in the progression of Alzheimer’s disease (AD).

Method: Recently, it was discovered that platelets, which make up 90% of the circulatory Aβ, encourage the development of AD. Therefore, we hypothesized to use a novel coumarin derivative PS21HKR, which is believed to possess anti-platelet and anti-inflammatory properties for the treatment of AD. We investigated the effects of PS21HKR on STZ induced cognitive decline and neuroinflammation. Intra-cerebroventricular streptozotocin (ICV-STZ) (3mg/Kg) induced Wistar rat models of AD were used in the study. Rats were divided into 3 groups including sham, STZ and PS21HKR group.

Result: Behavioural studies revealed that PS21HKR mitigates the cognitive deficit associated with STZ. Anti-platelet effect of PS21HKR was confirmed by tail vein bleeding assay. Further, in-vitro studies were performed on BV2 cells including the MTT assay and determination of expression of inflammatory markers. The results suggested that PS21HKR potentially regulated the expression of pro- and anti-inflammatory cytokines.

Conclusion: Therefore, findings of this study indicate that PS21HKR has a potent neuroprotective effect by virtue of its anti-platelet and anti-inflammatory activity

Mr. Prajjwal Sharma is a dedicated professional based in Bathinda, India, currently affiliated with the Central University of Punjab in Bathinda, Punjab. He brings a wealth of knowledge and expertise to his role at the institution.