Background and Objectives:Parkinson's disease is a common neuropathological disorder caused bydegeneration of dopaminergic neurons in substantia nigra pars compacta. The aim of this study was to investigate the evaluation of synergism effect of combinational treatment of epicathechine and edaravone with Madopar on movement and behavior disorders in Parkinson model induced by 6 -Hydroxydopamine in male rats.Materials and Methods:In this experimental study, 40 male Wistar rats weighing 200-250 g were used. Rats were randomly divided into 5 groups of 8. Sham group did not receive any lesions. The Parkinson's group became Parkinson's in the anterior-middle group of the brain by unilateral injection of 4 micrograms of neurotoxin 6-hydroxy dopamine. The third group combines epicatechin (50 mg / kg, ip) -adaravone (10 mg / kg, ip), the fourth group Madopar (50 mg / kg, gavage) and the fifth group epicatin-adarvon-madopar fifth after The induction of Parkinson's model was treated for 14 days and then behavioral tests including balance test (narrow duct test), apomorphine-induced rotational test and open field were performed.Results:Establishment of Parkinson's model by injecting 6-hydroxy dopamine into rats caused a significant increase in the number of rotations induced by apomorphine, total balance test time and change in open field test compared to the control group (p

Ramin Ataee is a researcher associated with the Medicinal Plants Research Center at Mazandaran University of Medical Sciences in Sari, Iran. His work primarily focuses on the study and exploration of medicinal plants, contributing to the understanding of their potential health benefits and applications in medical science. Through his research, Ataee aims to uncover the therapeutic properties of various plant species, thereby advancing the field of natural medicine and supporting the development of alternative treatment options.