The United States is grappling with a surge in adult obesity, with over 100 million individuals aged 20 and above, constituting 33% of the population, facing this health issue. Alarming trends extend to adolescents, where 18% of 6-11-year-olds and 21% of 12-19-year-olds are categorized as obese. Despite national goals to reduce adult obesity by 10% in 2021, recent data suggests stagnation. Hopkins GIM researchers are exploring the historical context and challenges of obesity while actively seeking innovative strategies and interventions to address this pervasive health concern.