Click chemistry, initially coined by Sharpless and colleagues, involves a selection of reactions that produce simple, and high-yield compounds. These reactions are easy to perform, generate products efficiently with minimal side products, and work well under various conditions. One of the most widely used click reactions is the copper(I)-catalysed azide-alkyne cycloaddition (CuAAC) reaction. However, it has disadvantages due to copper’s cytotoxicity, which can lead to Alzheimer’s, neurological disorders, and hepatitis with excessive consumption. To create more complexity while being simple, these reactions are combined with multicomponent reactions. In this regard, multicomponent reactions (MCRs) represent a significant advancement in chemical synthesis. These convergent reactions involve three or more starting materials, resulting in complex molecules where most or all atoms contribute to the final product. MCRs facilitate the formation of multiple bonds and offer a streamlined approach to creating diverse compounds. In this presentation, we intend to review recent developments in the CuAAC reaction in multicomponent reactions.

Seyedmohammad Hosseininezhad received his B.Sc in Pure Chemistry from Payam Noor University in 2020 as a first-ranked student. Then, he received his M.Sc in Organic Chemistry with a GPA of 4 out of 4 from Babol Noshirvani University of Technology in 2023. He currently works as research assistant at the University of Zanjan under the supervision of Prof. Ali Ramazani. His studies are focused on organic synthesis, medicinal chemistry and nanochemistry. He published 4 ISI articles and 5 conference papers. Also, he contributes to 6 international book chapters as the first author. He is a member of the Royal Society of Chemistry.