The use of depot progesterone as a contraceptive every three months by a considerable number of Women has raised concerns regarding the potential for hormones and chemicals to trigger fatal immune Responses resulting in skin reactions. The focus of our case report is a 25-year-old woman who suffered a fatal dermatological condition after using this contraceptive. It is noteworthy that this specific Condition has not been documented in medical literature before.Keywords:Depot progesterone, fatal dermatology lesion, acantholysis, hypersensitivity response

I am Dr. Aisha Rehma Siddiqui MD, an ECFMG certified postgraduate trainee currently working in a tertiary care hospital in Pakistan. I have research experience and have published 10 papers in renowned journals.