The core objective in drug design is to foresee whether a given particle will bind to a target and if so how unequivocally. Molecular mechanics or molecular dynamics are commonly used to predict the conformation of the little particle and to model conformational changes in the biological targets that may happen when the little molecules are tied to it. The corrective reaction of a drug relies on the cooperation of drug molecules with cell on cell membrane related biological events at receptor sites in a concentration dependent manner.