ABSTRACTObjective: The major goal of this current experimental study was to use various hydrotropic agents in the formation of solid dispersion-based hydrotropic blends to improve the solubility properties of poor aqueous soluble drug atorvastatin calcium (ATV). Since, atorvastatin calcium has a solubility in aqueous solutions of greater than 0.1 mg/ml, which is very slightly soluble. When developing dosage forms for these medications, formulation scientists still face challenges.Methods: In this study, twenty-two distinct binary, ternary, and quaternary formulations of ATV were prepared by employing five different hydrotropic agents (sodium benzoate, sodium salicylate, resorcinol, d-mannitol, and PEG 6000), and combining at least two hydrotropic agents in concentrations of 10% and 20% (w/v). Moreover, four different solid dispersions by the solvent evaporation method and physical mixture-based hydrotropic blends in the ratio of (1:2) have been formulated. The produced formulations were characterized using an FTIR analysis.Results and discussion: According to the findings, binary formulations containing 20% (w/v) concentrations of sodium benzoate (SB), sodium salicylate (SS), and resorcinol (R) boosted the solubility ratio of ATV by 439.31, 689.57, and 106.21 folds, respectively. Furthermore, ternary formulations (FT14) and quaternary formulations (FQ18) resulted in the enhancement of ATV solubility by 938.45 and 995.12 folds, respectively. Ternary solid dispersion demonstrated the highest enhancement in solubility ratio by 87.68 folds and resulted in a higher dissolution rate of ATV than pure samples of the drug. Finally, FTIR analyses ruled out any interactions between medications and excipients by showing no noticeable shift in the peaks. Conclusion: Solid dispersion-based hydrotropic blends can provide the production of the dosage forms of practically insoluble drugs with a favorable enhancement ratio in solubility.

My name is Suren Azad Ramadhan, and I am a pharmaceutical specialist in pharmaceutics. I hold a Bachelor's degree in Pharmaceutical Sciences, and a Master's degree in Pharmaceutics, and I am currently pursuing a PhD in the same field. Additionally, I am a health awareness activist. I work as a Lecturer of Industrial Pharmacy, Cosmeceutical Sciences, and Biopharmaceutics & Pharmacokinetics at the College of Pharmacy, Pharmaceutics Department at Knowledge University. Since 2016, I have been active in the Kurdistan pharmaceutical market, assuming various roles until I arrived at my current position as a Product and Marketing Manager in March 2021. Throughout my professional career, I have had the privilege of being involved in numerous national and international symposiums and conferences, taking on various roles such as attendee, speaker, and member of the organizing committee. These experiences have provided me with valuable opportunities to expand my knowledge, network with professionals in my field, and contribute to the advancement of research and innovation.